Fig. 3

EMT exosomal lncRNA profile. A Heatmap diagram of differentially expressed lncRNAs (DElncRNAs) between EMT-exo and non-EMT-exo. Red, upregulated; green, downregulated. B Top 20 KEGG enriched pathways. Pathways are indicated on the left, enrichment is indicated on the right, and the size of the circle is proportional to the number of genes. C Validation of five selected DElncRNAs. NEAT1, nuclear paraspeckle assembly transcript 1; SNHG3, small nucleolar RNA host gene 3; SNHG10, small nucleolar RNA host gene 10; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; KCNQ1OT1, KCNQ1 opposite strand/antisense transcript 1. D Expression of lncRNA SNHG10 in CRC tumor tissues (n = 30) and adjacent normal tissues (n = 30). E Receiver operating characteristic (ROC) curve of lncRNA SNHG10. The area under the ROC curve was 0.8489 (95% confidence interval 0.7524–0.9454). F Expression level of lncRNA SNHG10 in colon adenocarcinoma tissues (COAD, n = 473) and adjacent tissues (n = 41) from the GDC database. G Analysis of the prognosis of lncRNA SNHG10 in COAD (n = 453) from the TCGA database. t-test, *P < 0.05, **P < 0.01