Fig. 3
From: EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway
EZR promotes PC cells proliferation, invasion and migration. A RT-qPCR identified the expression of EZR was lower in si-EZR1/2-transfected cells than corresponding negative control group cells. B, C CCK-8 assay showed that down-regulation of EZR significantly reduced cell viability in PC cell lines. D si-EZR1/2 of MIA PaCa-2 and PANC-1 cells suppressed the colony formation ability respectively. F, G the cell migratory and invasive capacity of si-EZR1/2(MIA PaCa-2 and PANC-1 cells) were significantly repressed. The images of data quantification of E colony formation, H transwell migration and I invasion assays. *p < 0.05, **p < 0.01, ***p < 0.001