Fig. 5
From: EZR promotes pancreatic cancer proliferation and metastasis by activating FAK/AKT signaling pathway
The effect of EZR on the FAK/AKT signaling pathway. A FAK was to predicted to have a positive correlation with EZR in PC using GEPIA (http://gepia.cancer-pku.cn/) (p  = 0.00016). B, C Immunoprecipitation (IP) and RT-qPCR comfirmed the positive correlation between EZR and FAK. D–G Western Blot showed that si-EZR could inhibit the expression of p-FAK, p-PI3K and p-AKT, but could not decrease the total expression level of FAK, PI3K and AKT in MIA PaCa-2 (D, F) and PANC-1cell lines (E, G). *p < 0.05, **p < 0.01, ***p < 0.001