Table 2 The information of licorice’s targets
UniProt-ID | Protein names | Gene names | Degree | Species |
|---|---|---|---|---|
P0DP23 | Calmodulin-1 | CALM1 | 19 | Homo sapiens |
P35368 | Alpha-1B adrenergic receptor | ADRA1B | 5 | homo sapiens |
P00918 | Carbonic anhydrase 2 | CA2 | 17 | Homo sapiens |
P18031 | Tyrosine-protein phosphatase non-receptor type 1 | PTPN1 | 17 | Homo sapiens |
P46098 | 5-hydroxytryptamine receptor 3A | HTR3A | 1 | Homo sapiens |
P20309 | Muscarinic acetylcholine receptor M3 | CHRM3 | 3 | Homo sapiens |
P23219 | Prostaglandin G/H synthase 1 | PTGS1 | 8 | Homo sapiens |
Q14524 | Sodium channel protein type 5 subunit alpha | SCN5A | 11 | Homo sapiens |
P07477 | Trypsin-1 | PRSS1 | 18 | Homo sapiens |
P17612 | cAMP-dependent protein kinase catalytic subunit alpha | PRKACA | 6 | Homo sapiens |
O14757 | Serine/threonine-protein kinase | CHEK1 | 18 | Homo sapiens |
P11309 | Serine/threonine-protein kinase pim-1 | PIM1 | 20 | Homo sapiens |
P35354 | Prostaglandin G/H synthase 2 | PTGS2 | 20 | Homo sapiens |
P27487 | Dipeptidyl peptidase 4 | DPP4 | 13 | Homo sapiens |
Q16539 | Mitogen-activated protein kinase 14 | MAPK14 | 13 | Homo sapiens |
P48736 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | PIK3CG | 3 | Homo sapiens |
P21730 | C5a anaphylatoxin chemotactic receptor 1 | AR | 22 | Homo sapiens |
P49841 | Glycogen synthase kinase-3 beta | GSK3B | 17 | Homo sapiens |
P24941 | Cyclin-dependent kinase 2 | CDK2 | 17 | Homo sapiens |
Q92731 | Estrogen receptor beta | ESR2 | 16 | Homo sapiens |
P07900 | Heat shock protein HSP 90-alpha | HSP90AA1 | 12 | Homo sapiens |
P20248 | Cyclin-A2 | CCNA2 | 20 | Homo sapiens |
B2RXH2 | Lysine-specific demethylase 4E | KDM4E | 1 | Homo sapiens |
O00767 | Stearoyl-CoA desaturase | SCD | 10 | Homo sapiens |
O95622 | Adenylate cyclase type 5 | ADCY5 | 7 | Homo sapiens |
P08842 | Steryl-sulfatase | STS | 13 | Homo sapiens |
P11474 | Steroid hormone receptor ERR1 | ESRRA | 12 | Homo sapiens |
P12644 | Bone morphogenetic protein 4 | BMP4 | 1 | Homo sapiens |
P16152 | Carbonyl reductase [NADPH] 1 | CBR1 | 7 | Homo sapiens |
P28223 | 5-hydroxytryptamine receptor 2A | HTR2A | 18 | Homo sapiens |
P51843 | Nuclear receptor subfamily 0 group B member 1 | NR0B1 | 7 | Homo sapiens |
Q99814 | Endothelial PAS domain-containing protein 1 | EPAS1 | 3 | Homo sapiens |
Q9Y263 | Phospholipase A-2-activating protein | PLAA | 3 | Homo sapiens |
O60218 | Aldo–keto reductase family 1 member B10 | AKR1B10 | 1 | Homo sapiens |
P05093 | Steroid 17-alpha-hydroxylase/17,20 lyase | CYP17A1 | 1 | Homo sapiens |
P10276 | Retinoic acid receptor alpha | RARA | 1 | Homo sapiens |
P11413 | Glucose-6-phosphate 1-dehydrogenase | G6PD | 1 | Homo sapiens |
P11473 | Vitamin D3 receptor | VDR | 1 | Homo sapiens |
P16662 | UDP-glucuronosyltransferase 2B7 | UGT2B7 | 1 | Homo sapiens |
P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | SRD5A1 | 1 | Homo sapiens |
P19793 | Retinoic acid receptor RXR-alpha | RXRA | 7 | Homo sapiens |
P36873 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit | PPP1CC | 1 | Homo sapiens |
P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | HSD11B2 | 2 | Homo sapiens |
Q08828 | Adenylate cyclase type 1 | ADCY1 | 1 | Homo sapiens |
Q12908 | Ileal sodium/bile acid cotransporter | SLC10A2 | 1 | Homo sapiens |
Q9NRD8 | Dual oxidase 2 | DUOX2 | 1 | Homo sapiens |
Q9UBM7 | 7-dehydrocholesterol reductase | DHCR7 | 1 | Homo sapiens |
P03372 | Estrogen receptor | ESR1 | 13 | Homo sapiens |
P03420 | Fusion glycoprotein F2 | F2 | 18 | Homo sapiens |
P37231 | Peroxisome proliferator-activated receptor gamma | PPARG | 19 | Homo sapiens |
P30291 | Wee1-like protein kinase | WEE1 | 3 | Homo sapiens |
P23141 | Liver carboxylesterase 1 | CES2 | 7 | Homo sapiens |
P05067 | Amyloid-beta precursor protein | APP | 7 | Homo sapiens |
P09960 | Leukotriene A-4 hydrolase | LTA4H | 10 | Homo sapiens |
P10636 | Microtubule-associated protein tau | MAPT | 9 | Homo sapiens |
Q04206 | Transcription factor p65 | RELA | 6 | Homo sapiens |
P22303 | Acetylcholinesterase | ACHE | 11 | Homo sapiens |
Q15596 | Nuclear receptor coactivator 2 | NCOA2 | 10 | Homo sapiens |
P11388 | DNA topoisomerase 2-alpha | TOP2A | 11 | Homo sapiens |
P35968 | Vascular endothelial growth factor receptor 2 | KDR | 8 | Homo sapiens |
P00742 | Coagulation factor X | F10 | 16 | Homo sapiens |
P08709 | Coagulation factor VII, EC 3.4.21.21 | F7 | 7 | Homo sapiens |
P11926 | Ornithine decarboxylase | ODC1 | 10 | Homo sapiens |
P14061 | 17-beta-hydroxysteroid dehydrogenase type 1 | HSD17B1 | 5 | Homo sapiens |
P18054 | Olyunsaturated fatty acid lipoxygenase ALOX12 | ALOX12 | 7 | Homo sapiens |
Q9UHC3 | Acid-sensing ion channel 3 | ASIC3 | 12 | Homo sapiens |
P05091 | Aldehyde dehydrogenase | ALDH2 | 4 | Homo sapiens |
P37058 | Testosterone 17-beta-dehydrogenase 3 | HSD17B3 | 3 | Homo sapiens |
Q13887 | Krueppel-like factor 5 | KLF5 | 2 | Homo sapiens |
Q15788 | Nuclear receptor coactivator 1 | NCOA1 | 6 | Homo sapiens |
Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH2 | 5 | Homo sapiens |
Q9H4B7 | Tubulin beta-1 chain | TUBB1 | 5 | Homo sapiens |
P12268 | Inosine-5'-monophosphate dehydrogenase 2 | IMPDH2 | 1 | Homo sapiens |
P11308 | Transcriptional regulator ERG | ERG | 1 | Homo sapiens |
P45985 | Dual specificity mitogen-activated protein kinase kinase 4 | MAP2K4 | 1 | Homo sapiens |
P25100 | Alpha-1D adrenergic receptor | ADRA1D | 2 | Homo sapiens |
P36544 | Neuronal acetylcholine receptor subunit alpha-7 | CHRNA7 | 1 | Homo sapiens |
P28702 | Retinoic acid receptor RXR-beta | RXRB | 2 | Homo sapiens |
P08912 | Muscarinic acetylcholine receptor M5 | CHRM5 | 1 | Homo sapiens |
P11229 | Muscarinic acetylcholine receptor M1 | CHRM1 | 2 | Homo sapiens |
P07550 | Beta-2 adrenergic receptor | ADRB2 | 4 | Homo sapiens |
P35372 | Mu-type opioid receptor | OPRM1 | 1 | Homo sapiens |
P41143 | Delta-type opioid receptor | OPRD1 | 1 | Homo sapiens |
O60502 | Protein O-GlcNAcase | OGA | 1 | homo sapiens |
P08514 | Integrin alpha-IIb | ITGA2B | 1 | Homo sapiens |
P16278 | Beta-galactosidase | GLB1 | 1 | Homo sapiens |
P28838 | Cytosol aminopeptidase | LAP3 | 1 | Homo sapiens |
P31639 | Sodium/glucose cotransporter 2 | SLC5A2 | 1 | Homo sapiens |
P53396 | ATP-citrate synthase | ACLY | 1 | Homo sapiens |
P54577 | Tyrosine–tRNA ligase, cytoplasmic | YARS | 1 | Homo sapiens |
O75907 | Diacylglycerol O-acyltransferase 1 | DGAT1 | 3 | Homo sapiens |
P14222 | Perforin-1 | PRF1 | 1 | Homo sapiens |
P51684 | C–C chemokine receptor type 6 | CCR6 | 2 | Homo sapiens |
P05177 | Cytochrome P450 1A2 | CYP1A2 | 1 | Homo sapiens |
Q16678 | Cytochrome P450 1B1 | CYP1B1 | 1 | Homo sapiens |
Q92959 | Solute carrier organic anion transporter family member 2A1 | SLCO2A1 | 1 | Homo sapiens |
P29474 | Nitric oxide synthase | NOS3 | 2 | Homo sapiens |
P08684 | Cytochrome P450 3A4 | CYP3A4 | 1 | Homo sapiens |
P09211 | Glutathione S-transferase P | GSTP1 | 2 | Homo sapiens |
Q99835 | Smoothened homolog | SMO | 1 | Homo sapiens |
Q9NYA1 | Sphingosine kinase 1 | SPHK1 | 1 | Homo sapiens |
P48039 | Melatonin receptor type 1A | MTNR1A | 1 | Homo sapiens |
Q03181 | Peroxisome proliferator-activated receptor delta | PPARD | 1 | Homo sapiens |
P10145 | Interleukin-8 | CXCL8 | 1 | Homo sapiens |
P62993 | Growth factor receptor-bound protein 2 | GRB2 | 1 | Homo sapiens |
P01857 | Immunoglobulin heavy constant gamma 1 | IGHG1 | 2 | Homo sapiens |
P35228 | Nitric oxide synthase | NOS2 | 20 | Homo sapiens |
P04798 | Cytochrome P450 1A1 | CYP1A1 | 4 | Homo sapiens |
Q12791 | Calcium-activated potassium channel subunit alpha-1 | KCNMA1 | 1 | Homo sapiens |