Table 1 Cancer biomarker information of top-ranked CREB1 targets
From: Systematical analysis reveals a strong cancer relevance of CREB1-regulated genes
Gene | Up-/down-regulated | Oncogene (+)/tumor suppressor gene (−) | Biomarker/potential biomarker |
|---|---|---|---|
BDKRB2 | ↑ | +  | Cervical cancer [38] |
HLA-F | ↑ | +  | |
VGF | ↑ | +  | Pulmonary neuroendocrine tumors [42]; urothelial cell carcinoma [43] |
STC2 | ↑ | +  | Esophageal squamous cell carcinoma [44]; renal cell carcinoma [45]; colorectal cancer [46] |
NCALD | ↑ | +  | Cytogenetic normal acute myeloid leukemia [47]; ovarian cancer [48] |
BRCA1 | ↑ | − | Sporadic epithelial ovarian carcinoma [49]; breast cancer[50] |
HOXA4 | ↑ | − | Lung cancer [51] |
SIX1 | ↑ | +  | Stage I–III colorectal cancer [39]; cervical cancer [52]; KRAS/LKB1-mutant lung cancer [53] |
BTN3A2 | ↑ | − | Triple-negative breast cancer [54]; pancreatic ductal [55]; adenocarcinoma [56] |
ABCG2 | ↑ | +  | Cancer stem cell [57] |
UBE2D1 | ↑ | +  | Lung adenocarcinoma [58] |
TAF1A | ↑ | +  | Cervical cancer [59] |
EPHA7 | ↓ | − | Immune checkpoint inhibitors in multiple cancers [60] |
USP11 | ↓ | +  | |
RBM3 | ↓ | − | Head and neck squamous cell carcinoma [63] |