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Fig. 5 | Cancer Cell International

Fig. 5

From: Constitutive TDO2 expression promotes liver cancer progression by an autocrine IL-6 signaling pathway

Fig. 5

Suppression of AhR signals improved the anticancer effects of chemotherapy. A The tumor volume of SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. B Survival analysis of SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. C The tumor volume of SMC-7721 bearing mice treated with PBS, PDM2, 5-FU and PDM2 combining 5-FU. D Survival analysis of SMC-7721 bearing mice treated with PBS, PDM2, 5-FU and PDM2 combining 5-FU. E, Expression of IL-6, AhR, p-STAT3, total STAT3 and NF-kB in Vector (Vec) or TDO2 overexpression (OE) SMC-7721 tumor tissues using Elisa or western blotting analysis. F The tumor volume of TDO2 overexpression SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. G, Survival analysis of TDO2 overexpression SMC-7721 bearing mice treated with PBS, PDM2, DOX and PDM2 combining DOX. *p < 0.05, **p < 0.01

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