Fig. 1
From: Role of PRKDC in cancer initiation, progression, and treatment
The overall structure of DNA-PKcs (PDB id: 6ZFP). The structural domains are colored according to the schematic shown below the structures. The N terminus is shown in purple, the circular cradle in orange, the FAT domain in teal, and the kinase domain in yellow. (Reference: Chaplin AK, Hardwick SW, Liang S et al. Dimers of DNA-PK create a stage for DNA double-strand break repair. Nature Structural & Molecular Biology 2021, 28(1):13–19.)