Fig. 6
Switching of 3D migration mode. During 3D migration, changes in the surrounding environment can stimulate cells to switch between three migration modes155,160,161, which include amoeboid migration with blebbing as the main method [156, 162], in addition to mesenchymal, and lobopodial migration. Amoeboid migration is dependent on RhoC-signaling and cells switch to mesenchymal migration when the RhoC signal is blocked [134, 158]. However, when the cells reside in a limited 3D matrix, or the intracellular pressure increases, cells switch to lobopodial migration mode [2].