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Fig. 10 | Cancer Cell International

Fig. 10

From: miR-140-3p is involved in the occurrence and metastasis of gastric cancer by regulating the stability of FAM83B

Fig. 10

Effects and mechanisms of miR-140-3p on the growth and metastasis of GC. First, miR-140-3p directly bound to SNHG12 in GC and thus down-regulated the expression of SNHG12and reduced the binding of SNHG12 and HuR, inhibiting the transportation of HuR from the nuclei to the cytoplasm. Therefore, the binding of HuR and FAM83B mRNA was inhibited and FAM83B mRNA’s stability was reduced, and the transcription of FAM83B was down-regulated. Furthermore, the proliferation, invasion, and migration of GC cells were inhibited and the growth and metastasis of GC were inhibited

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Cancer Cell International

ISSN: 1475-2867

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