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Table 1 Characteristics of included patients and analysis of liver metastasis tumors

From: Prognostic value of a novel biomarker combining DNA ploidy and tumor burden score for initially resectable liver metastases from patients with colorectal cancer

Parameters

Total patients (n, %)

Median age (years)

59.5 (25-84)

Age, years

 

 ≤ 60

75 (54.0)

 > 60

64 (46.0)

Sex

 

 Male

86 (61.9)

 Female

53 (38.1)

Primary tumor location

 

 Colon

97 (69.8)

 Rectum

42 (30.2)

Primary tumor differentiation

 

 Well to moderate

108 (77.7)

 Poor

31 (22.3)

T stage

 

 T1–3

96 (69.1)

 T4

43 (30.9)

N stage

 

 N0

50 (36.0)

 N1–2

89 (64.0)

Timing of liver metastases

 

 Synchronous

75 (54.0)

 Metachronous

64(46.0)

Number of liver metastases

 

 1

91 (65.5)

 2

29 (20.9)

 3

12(8.6)

 4

4 (2.9)

 5

3 (2.2)

Liver metastases diameter (cm)

 

 Median (range)

2.5 (0.5-8.4)

 ≤ 3

99 (71.2)

 > 3

40 (28.8)

Distribution of liver metastases

 

 Unilobar

117 (84.2)

 Bilobar

22 (15.8)

TBS

 

 Median (range)

2.83 (1.12-8.46)

 ≤ 3

77 (55.4)

 > 3

62 (44.6)

 Median liver resection margin (cm)

0.8 (0-3.5)

Adjuvant chemotherapy after liver resection

 

 Yes

85 (61.2)

 No

54 (38.8)

DNA ploidy

 

 Diploid

32 (23.0)

 Aneuploid

95 (68.3)

 Tetraploid

12 (8.6)

Stroma fraction

 

 Low stroma

85 (61.2)

 High stroma

54 (38.8)

Nucleotyping

 

 Chromatin homogeneous

79 (56.8)

 Chromatin heterogeneous

60 (43.2)

  1. TBS tumor burden score