Table 2 Univariate and multivariate analyses of risk factors influencing RFS after liver resection
Variable | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95 % CI) | P value | HR (95 % CI) | P value | |
Age (> 60 years vs. ≤ 60 years) | 0.677 (0.408-1.123) | 0.131 |  |  |
Sex (Male vs. Female) | 0.961 (0.583-1.585) | 0.877 | Â | Â |
Primary tumor location (Rectum vs. Colon) | 1.373 (0.824-2.290) | 0.224 | Â | Â |
Primary tumor differentiation (Poor vs. Well to moderate) | 1.246 (0.707-2.194) | 0.447 | Â | Â |
T stage (T4 vs. T1–3) | 1.234 (0.731-2.082) | 0.431 |  |  |
 N stage (N1–2 vs. N0) | 3.067 (1.663-5.656) | < 0.001 | 3.260 (1.765-6.023) | < 0.001 |
Timing of liver metastasis (Synchronous vs. Metachronous) | 0.796 (0.487-1.302) | 0.364 | Â | Â |
TBS (>3 vs. ≤3) | 1.863(1.137-3.050) | 0.013 | 1.817 (1.106-2.984) | 0.018 |
Adjuvant chemotherapy after liver resection (Yes vs. No) | 1.292 (0.748-2.231) | 0.359 | Â | Â |
DNA ploidy (Nondiploid vs. Diploid) | 1.997 (1.016-3.925) | 0.045 | 2.082 (1.053-4.115) | 0.035 |
Stroma fraction (High stroma vs. Low stroma) | 0.801 (0.478-1.343) | 0.400 | Â | Â |
Nucleotyping (Chromatin heterogeneous vs. Chromatin homogeneous) | 1.184 (0.724-1.939) | 0.501 | Â | Â |