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Fig. 2 | Cancer Cell International

Fig. 2

From: Hypomethylation and downregulation of miR-23b-3p are associated with upregulated PLAU: a diagnostic and prognostic biomarker in head and neck squamous cell carcinoma

Fig. 2

Hypomethylation of PLAU and its prognostic value in HNSCC. a PLAU was significantly hypomethylated in HNSCC tissues compared to the normal group. b PLAU methylation was negatively associated with PLAU expression. c No significant association was found between PLAU expression and DNMT1 (left) or DNMT3A (middle) levels. The positive correlation between PLAU expression and DNTM3B was significant (right). d Higher methylation of PLAU predicted a longer survival time compared to hypomethylation. e Lower methylation was correlated with higher clinical stage (above) and more aggressive metastasis (below). f PLAU methylation was lower in p53 mutant group than in the nonmutant group

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