Hypomethylation and downregulation of miR-23b-3p are associated with upregulated PLAU: a diagnostic and prognostic biomarker in head and neck squamous cell carcinoma

Table 1 Association between PLAU expression and clinical variables in patients with HNSCC

Clinical variable	Number	PLAU expression	p-value
Sex
Male	368	7.96 ± 1.290	0.572
Female	134	8.05 ± 1.301	0.572
Age (years)
≥ 60	256	7.97 ± 1.280	0.748
< 60	221	7.98 ± 1.334	0.748
Tumor stage
T1	34	7.58 ± 1.342	0.088
T2	144	7.93 ± 1.296
T3	133	7.93 ± 1.232
T4	177	8.10 ± 1.277
Lymph metastasis
N0	241	7.94 ± 1.291	0.552
N1	81	8.10 ± 1.276
N2	136	7.99 ± 1.261
Clinical stage
I	25	7.90 ± 1.166	0.726
II	81	7.93 ± 1.199
III	90	7.99 ± 1.261
IV	306	8.00 ± 1.339
Smoking status
Yes	381	8.00 ± 1.252	0.529
No	111	7.93 ± 1.380	0.529

Complete data were unavailable in the TCGA database
^aTumor stage: T category of the TNM classification which described the primary tumor site and size
^bClinical stage: the TNM combinations were grouped into four less-detailed stages, including Stages I to Stage IV

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