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Fig. 4 | Cancer Cell International

Fig. 4

From: Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer

Fig. 4

a, b LASSO Cox regression analysis identified 9 genes significantly correlated with overall survival in TCGA training cohort. (a) Ten-fold cross-validations for screening of the optimal parameter (lambda). b LASSO coefficient profiles determined by the optimal lambda. c Forest plot presented the HRs and P-values from the univariate Cox regression as well as LASSO coefficients of the nine prognostic signature genes. di Heatmap visualizing the expression levels of nine prognostic CAF genes with the CAF risk scores in d TCGA training, e TCGA validation, f TCGA overall, g GSE39582, h GSE17536 and i HColA095Su01 tissue microarray cohort

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