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Table 1 Univariate and multivariate Cox proportional hazards regression analysis on OS

From: Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer

  Univariate analysis Multivariate analysis
HR 95% CI P HR 95% CI P
TCGA training cohort
 Age 1.023 0.999–1.049 0.06 1.033 1.008–1.058 0.009
 TNM stage 2.67 1.918–3.718  < 0.001 2.73 1.911–3.9  < 0.001
 CAF signature 4.418 2.521–7.744  < 0.001 3.161 1.828–5.468  < 0.001
TCGA validation cohort
 Age 1.061 1.024–1.099 0.001 1.058 1.023–1.094 0.001
 TNM stage 2.363 1.566–3.564  < 0.001 2.391 1.566–3.651  < 0.001
 CAF signature 2.323 1.094–4.932 0.028 1.334 0.609–2.920 0.471
TCGA total cohort
 Age 1.036 1.016–1.057  < 0.001 1.039 1.02–1.059  < 0.001
 TNM stage 2.553 1.973–3.304  < 0.001 2.568 1.962–3.361  < 0.001
 CAF signature 3.45 2.212–5.381  < 0.001 2.261 1.454–3.516  < 0.001
GSE39582 cohort
 Age 1.039 1.024–1.053  < 0.001 1.037 1.023–1.052  < 0.001
 TNM stage 1.688 1.315–2.167  < 0.001 1.646 1.272–2.13  < 0.001
 CAF signature 1.744 1.277–2.382  < 0.001 1.455 1.055–2.007 0.022
GSE17536 cohort
 Age 1.006 0.988–1.025 0.492 1.027 1.006–1.047 0.01
 TNM stage 2.855 2.112–3.859  < 0.001 3.323 2.373–4.653  < 0.001
 CAF signature 2.553 1.413–4.613 0.002 3.018 1.644–5.539  < 0.001
HColA095Su01 cohort
 Age 0.995 0.969–1.022 0.704 0.997 0.97–1.026 0.86
 TNM stage 1.069 0.631–1.811 0.803 1.239 0.714–2.148 0.446
 CAF signature 1.003 1.001–1.005 0.011 1.003 1.001–1.005 0.014
  1. OS overall survival, HR hazard ratio, CI Confidence interval, CAF Cancer associated fibroblast