Cancer Cell International

Table 1 Univariate and multivariate Cox proportional hazards regression analysis on OS

From: Integrated single-cell and bulk RNA sequencing analysis identifies a cancer associated fibroblast-related signature for predicting prognosis and therapeutic responses in colorectal cancer

	Univariate analysis			Multivariate analysis
	HR	95% CI	P	HR	95% CI	P
TCGA training cohort
Age	1.023	0.999–1.049	0.06	1.033	1.008–1.058	0.009
TNM stage	2.67	1.918–3.718	< 0.001	2.73	1.911–3.9	< 0.001
CAF signature	4.418	2.521–7.744	< 0.001	3.161	1.828–5.468	< 0.001
TCGA validation cohort
Age	1.061	1.024–1.099	0.001	1.058	1.023–1.094	0.001
TNM stage	2.363	1.566–3.564	< 0.001	2.391	1.566–3.651	< 0.001
CAF signature	2.323	1.094–4.932	0.028	1.334	0.609–2.920	0.471
TCGA total cohort
Age	1.036	1.016–1.057	< 0.001	1.039	1.02–1.059	< 0.001
TNM stage	2.553	1.973–3.304	< 0.001	2.568	1.962–3.361	< 0.001
CAF signature	3.45	2.212–5.381	< 0.001	2.261	1.454–3.516	< 0.001
GSE39582 cohort
Age	1.039	1.024–1.053	< 0.001	1.037	1.023–1.052	< 0.001
TNM stage	1.688	1.315–2.167	< 0.001	1.646	1.272–2.13	< 0.001
CAF signature	1.744	1.277–2.382	< 0.001	1.455	1.055–2.007	0.022
GSE17536 cohort
Age	1.006	0.988–1.025	0.492	1.027	1.006–1.047	0.01
TNM stage	2.855	2.112–3.859	< 0.001	3.323	2.373–4.653	< 0.001
CAF signature	2.553	1.413–4.613	0.002	3.018	1.644–5.539	< 0.001
HColA095Su01 cohort
Age	0.995	0.969–1.022	0.704	0.997	0.97–1.026	0.86
TNM stage	1.069	0.631–1.811	0.803	1.239	0.714–2.148	0.446
CAF signature	1.003	1.001–1.005	0.011	1.003	1.001–1.005	0.014

OS overall survival, HR hazard ratio, CI Confidence interval, CAF Cancer associated fibroblast

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