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Table 2 Predictive factors of OS

From: Carboxypeptidase N1 is anticipated to be a synergy metrics for chemotherapy effectiveness and prognostic significance in invasive breast cancer

Overall survival Univariate analysis Multivariate analysis
Cut off HR 95% CI P value HR 95% CI P value
Age (years) 60 1.053 0.552–2.008 0.875    
Tumor size (cm) 5 2.018 1.003–4.06 0.049* 0.751 0.205–2.753 0.666
T stage 3 1.696 1.081–2.662 0.022* 1.421 0.707–2.856 0.323
N stage 3 1.507 1.115–2.038 0.008* 2.18 0.875–5.433 0.094
Pathologic stage 3 1.02 0.751–1.384 0.612    
pT stage 3 2.3 1.332–3.971 0.003* 0.518 0.264–1.015 0.055
ER score 4 1.33 0.685–2.58 0.4    
PR score 4 0.4 0.156–1.023 0.047* 0.38 0.102–1.418 0.15
HER2 score 4 1.983 0.454–1.611 0.036* 0.508 0.254–1.154 0.51
KI67 score 4 0.825 0.293–2.323 0.716    
P53 score 4 1.024 0.541–1.939 0.475    
CPN1 score 4 3.438 1.784–6.624  < 0.001* 2.384 1.073–5.295 0.033*
  1. HR: Cox proportional hazard ratio, 95% CI: 95% confidence interval
  2. *Statistically significant (P < 0.05)