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Fig. 7 | Cancer Cell International

Fig. 7

From: Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Fig. 7

Exosomes released by BMSC promote EMT and the proliferation of OS cells. A Diagrammatic sketch of BMSCs and OS cell coculture; B-F The effect of BMSCs with or without treatment of GW4869 on OS cell migration and invasion was evaluated by Transwell migration (B, D), Transwell invasion (B, E) and Scratch assays (C, F); E Western blot analysis of EMT-related proteins following cocultured with BMSCs with or without treatment of GW4869; H-I The effect of BMSCs with or without treatment of GW4869 on OS cell proliferation was evaluated by EdU (H, J), colony-formation (I, K) and CCK-8 assays(L). M Western blot analysis of cell-cycle-related proteins following cocultured with BMSCs with or without treatment of GW4869. Data are presented as the means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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