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Fig. 9 | Cancer Cell International

Fig. 9

From: Exosomal transfer of miR-769-5p promotes osteosarcoma proliferation and metastasis by targeting DUSP16

Fig. 9

miR-769-5p derived from BMSCs exosomes promotes the metastasis and proliferation of OS cells. A The expression of miR-769-5p in BMSC-derived exosomes with or without transfected miR-769-5p inhibitor; B Relative miR-769-5p expression of OS cells cocultured with miR-769-5p inhibitor-BMSCs compared to BMSCs were detected by qRT-PCR; C-G cocultured OS cells migration and invasion abilities was evaluated by Scratch (C, E), Transwell migration (D, F) and Transwell invasion assays (D, G); H EMT-related proteins were detected by western blotting. I-M cocultured OS cells proliferation ability was evaluated by EdU (I, K), colony-formation (J, L) and CCK-8 assays (M); N Cell-cycle-related proteins were detected by western blotting. Data are presented as the means ± SD. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer Cell International

ISSN: 1475-2867

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