Fig. 10

ISG15 and CST2 influence PCa cells metastasis in vivo. a Protein expression of ISG15 and CST2 in PC3 and 22Rv1 stable cell lines. b The intensities of region of interest (ROI) were assessed in PC3 and 22Rv1 stable cell lines, n.s. no difference. c Bioluminescence images of tumor cell metastasis at 4 weeks. Color scale bar represents the intensity of the tumor from violet (low) to red (high). right panel: quantification of whole animal bioluminescence and plotted as total flux (photons/sec). d Bioluminescence images curves of the development of tumor cells metastases in shCtrl, shISG15 and shCST2 group. Data are shown as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001