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Fig. 2 | Cancer Cell International

Fig. 2

From: MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates

Fig. 2

Transactivation and dimerization of MAX-R60Q and N-MYC-P44L. A Luciferase activity (RLU) in HEK293 cells, transiently transfected with a reporter construct containing 6 E-boxes (6X E-box), and the wild-type or mutant HA-N-MYC or FLAG-MAX expression vectors or empty vector control. In the lower panel, corresponding Western blots confirm protein expression with Vinculin as control. B Immunoblots of co-IP experiments. Wild-type and mutant HA-N-MYC and FLAG-MAX were expressed by transient transfection in HEK293 cells. Lysates from input control and the corresponding immunoprecipitates were tested by Western blot

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Cancer Cell International

ISSN: 1475-2867

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