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Fig. 2 | Cancer Cell International

Fig. 2

From: Silencing of the lncRNA H19 enhances sensitivity to X-ray and carbon-ions through the miR-130a-3p /WNK3 signaling axis in NSCLC cells

Fig. 2

lncRNA H19 acts as a competing endogenous RNA by sponging miR-130a-3p. A Predicted miRNAs interacting with lncRNA H19. B Top: Binding site for miR-130a-3p in the H19 3′-UTR. Bottom: HEK-293 T cells were transfected with a miR-130a-3p mimic/NC and luciferase reporter vector containing the H19 3′-UTR (WT) or its mutant construct (Mut). The WT-NC value was set to “1.0”. C Colony formation ability after miR-130a-3p mimic transfection and irradiation. D Cell viability after miR-130a-3p mimic transfection and irradiation was measured by a CCK-8 assay. E Flow cytometric analysis of apoptosis after miR-130a-3p mimic transfection and irradiation. The data are presented as the mean ± SD values. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control group

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Cancer Cell International

ISSN: 1475-2867

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