Fig. 3
From: Long non-coding RNA HEIH: a novel tumor activator in multiple cancers
General functions and mechanisms of lncRNAs. A–C lncRNA’s function in the nucleus, D–H lncRNA’s function in the cytoplasm. A LnRNA1 functions to modify chromatin protein through recruiting the complex of PRC2, resulting in suppression of gene expression. B LnRNA2 binds to the promoter of gene A and blocks the binding of transcription factors, thus affecting transcription initiation of gene A. C LnRNA3 functions to modulate the pool of modified splicing factor, thereby influencing gene splicing. D LnRNA4 acts as miRNA sponge and interacts with miRNA to form a complex and, thus, inhibits the binding of miRNA to the 3' UTR of target mRNA. E LnRNA5 interacts with translational factors to inhibit translation. F LnRNA6 serves as natural antisense inhibitor to promote degradation of mRNA