Table 1 Functional characterizations of HEIH in multiple human cancers
From: Long non-coding RNA HEIH: a novel tumor activator in multiple cancers
Cancer types | Expression | Role | Targets/regulators and related pathways | Function | Clinical correlation | Reference (PMID) |
|---|---|---|---|---|---|---|
Hepatocellular carcinoma | Upregulated | Oncogenic | miR-98-5p/PI3K/AKT, miR-199a-3p/mTOR, EZH2 | Proliferation, differentiation, Migration, apoptosis, metastasis, cell cycle | Prognosis, recurrence, drug resistance | 29286922 32572917 32821157 21769904 |
Tongue squamous cell carcinoma | Upregulated | Oncogenic | miR-3619-5p/HDGF | Proliferation, apoptosis | Drug-resistance | 33130420 |
Gastric cancer | Upregulated | Oncogenic | miR-214-3p | Proliferation, migration, invasion, apoptosis | Prognosis, TNM stage, diagnosis, tumor size, overall survival time | 33015781 33226411 33877891 |
Esophageal cancer | Upregulated | Oncogenic | miR-185/KLK5, miR-4458/PBX3, P53 | Proliferation, invasion, migration, apoptosis | Prognosis, tumor size, infiltration depth, TNM stage, overall survival time, drug-resistance | 33223519 32449803 32729661 |
Colorectal cancer | Upregulated | Oncogenic | miR-939/Bcl-xL | Proliferation, apoptosis | Tumor size, invasion depth, poor prognosis | 29081216 |
Cholangiocarcinoma | Upregulated | Oncogenic | miR-98-5p/HECTD4 | Proliferation, migration, invasion | Tumor size | 32062383 |
Endometrial cancer | Upregulated | Oncogenic | MAPK | Proliferation, viability, apoptosis | Drug-resistance | 31650338 |
Ovarian cancer | Upregulated | Oncogenic | miR-3619-5p/CTTNBP2 | Proliferation, migration, invasion, senescence | Prognosis | 33110047 |
Prostate cancer | Downregulated | – | – | – | – | 25933431 |
Breast cancer | Upregulated | Oncogenic | miR-200b/PBX3, Wnt/β-catenin, miR-4458/SOCS1, miR-939-5p/NOS2 | Proliferation, apoptosis, metastasis, viability, migration and invasion | Prognosis, TNM stage, tumor size, lymph node metastasis, overall survival time | 31526439 31456112 33368266 |
Non–small cell lung carcinoma | Upregulated | Oncogenic | – | Proliferation, apoptosis, migration, invasion | – | 30230600 |
Retinoblastoma | Upregulated | Oncogenic | miR-194-5p/WEE1 | Proliferation, migration, invasion | TNM stage, optic nerve invasion, choroidal invasion, overall survival time | 33262604 |
Melanoma | Upregulated | Oncogenic | miR-200b | Proliferation, migration, invasion | Prognosis, clinical stages | 28487474 |
Nasopharyngeal carcinoma | Upregulated | Oncogenic | miR-193a-5p/ CDK8 | Proliferation, migration, invasion | – | 33577031 |
Head and neck squamous cell carcinoma | Downregulated | – | – | – | – | 29575229 |