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Table 1 Effects of resveratrol on cancer cell lines

From: Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation

Cell line/method Signaling pathway Mechanism Results Refs.
MCF-10A/Res NRF2–UGT1A8 pathway Overexpression of NRF2 and UGT1A8 Resveratrol can regulate the estrogen level in cells Zhou et al. [28]
MCF-10A/Res NRF2-mediated protective pathways   Res can induce apoptosis and increase the Nrf2 and inhibit the E2-induced breast cancer Singh et al. [35]
MCF-10F/Res induction of Nrf2 transformation into the nucleus through increasing NQO1 expression. (Nrf2-Keap1-ARE pathway) increase and decrease the expression of NQO1 and CYP, respectively Resveratrol is a chemopreventive for breast cancer and decreases estrogen metabolism Fang et al. [36]
MCF10A/Res Nrf2 and BCR1 Overexpression of Nrf2 can reduce oxidative stress and prevent the tumorigenesis of the BCR1 gene Resveratrol and sulforaphane decrease the ROS accumulation via activation of Nrf2 expression Hyo et al. [37]
MCF-10A, MCF-10F/ HPIMBD, TIMBD   increase the expression of NQO1 and SOD3 and activation of Nrf2 HPIMBD and TIMBD can prevent breast cancer due to their antioxidant properties Anwesha et al. [29]
RA-FLS/Res Nrf2-Keap1 Overexpression of Nrf2 and reduction in the expression of Keap1, reduction in the ROS and MDA production Induction of apoptosis through Bcl2, inhibition of cell migration and proliferation, restoring the ROS accumulation caused by H2O2 Zhang et al. [30]
A549/Res Nrf2-Keap1 Res loaded in nanoparticles compared to Res showed the better effects in the elevation of Nrf2 level Activation of Nrf2-Keap1 pathway, restoring the ROS accumulation caused by H2O2 Kim et al. [20]
Animal study in mice/Res Nrf2/HO-1 pathway Suppress the IL-8, NF-κB, and iNOS expression and also increase in the HO-1 and Nrf2 Res can activate the Nrf2/HO-1 pathway Zhang et al. [38]
An animal study in rats with oxidative stress damage in hepatocytes/Res   Increase in the Nrf2 mRNA concentration and antioxidant enzymes (e.g. catalase, glutathione peroxidase, and also superoxide dismutase Res can protect the hepatocytes in oxidative stress conditions Rubiolo et al. [39]
HL-60/ effects of Res in a leukemia cell line that is resistant to ADR PI3K/Akt/Nrf2
PI3K/Akt/Nrf2 expression are decreased in cell line Res showed the antiproliferative activity against the cell line and promote the inhibition of cells by ADR Yongjun et al. [25]
Human keratinocytes/Res Nrf2–KEAP1 pathway Activation of antioxidant in the skin, Increase in the glutathione peroxidase-2, glutamylcysteinyl ligase, and GSH Res protects the skin cells from oxidative stress Soeur et al. [32]
A375SM/Res   Increase in the p27, and p21 gene expression and reduction of Bcl-2, Nrf2, and cyclin B expression Res can induce cell cycle arrest and apoptosis and inhibit the cell's proliferation but in contrast, it elevates ROS production and oxidative stress HEO et al. [33]
Animal study in male Wistar rats with renal carcinoma/ Res + sitagliptin Nrf2/HO-1 pathway, STAT3/NF-κB signaling Reduction in the TNF-α, STAT3, LDH, TGF-β1, and IL-6. Res suppress the expression of P-glycoprotein sitagliptin and Res improve kidney function in rats. They suppress inflammation and oxidative stress and have better effects when they are used together Kabel et al. [40]
HEK293/Res   Increase in the repair enzyme of DNA, OGG1, GSH, and decrease in the expression of Nrf2 Res has antioxidant and anticancer effects and Increases repair enzymes of DNA, Res can remove the toxicity of OTA Raghubeer et al. [34]
Pancreatic cancer cell line/Res ROS/Nrf2 Pathways Downregulation of NAF-1, induction of ROS accumulation, activation of Nrf2 Res can inhibit the proliferation and induce apoptosis in cancer cells Cheng et al. [13]
MSTO-211H/combination of Res with clofarabine PI3K/Akt signaling Inactivation of Nrf2, suppression of HO-1 High Inhibitory effects on growth cells when they were used together Lee et al. [31]
oogonial stem cell/Res   Activation of Nrf2 Res restore the oxidative stress and by chemotherapy in oogonial stem cells. it can reduce the H2O2 and cytotoxicity effects of chemotherapy Meng et al. [15]
  1. Res Resveratrol, E2 17β-estradiol, UGT1A8 UDP-glucuronosyltransferase 1A8, AhR hydrocarbon receptor, CYP cytochrome P450, NQO1 NAD(P)H quinone oxidoreductase 1, SOD3 superoxide dismutase 3, RA-FLS rheumatoid arthritis fibroblast-like synoviocyte, MDA malondialdehyde, HO-1 Heme Oxygenase-1, ADR adriamycin, TIMBD 4-(E)-(p-tolylimino)-methylbenzene-1,2-diol, HPIMBD 4-(E)-(4-hydroxyphenylimino)-methylbenzene, 1, 2-diol, OGG1 oxoguanine glycosylase 1, GSH glutathione, OTA ochratoxin A, NAF-1 nutrient-deprivation autophagy factor-1, HO-1 heme oxygenase-1