Table 1 Effects of resveratrol on cancer cell lines
From: Resveratrol mediates its anti-cancer effects by Nrf2 signaling pathway activation
| Cell line/method | Signaling pathway | Mechanism | Results | Refs. |
|---|---|---|---|---|
| MCF-10A/Res | NRF2–UGT1A8 pathway | Overexpression of NRF2 and UGT1A8 | Resveratrol can regulate the estrogen level in cells | Zhou et al. [28] |
| MCF-10A/Res | NRF2-mediated protective pathways | Res can induce apoptosis and increase the Nrf2 and inhibit the E2-induced breast cancer | Singh et al. [35] | |
| MCF-10F/Res | induction of Nrf2 transformation into the nucleus through increasing NQO1 expression. (Nrf2-Keap1-ARE pathway) | increase and decrease the expression of NQO1 and CYP, respectively | Resveratrol is a chemopreventive for breast cancer and decreases estrogen metabolism | Fang et al. [36] |
| MCF10A/Res | Nrf2 and BCR1 | Overexpression of Nrf2 can reduce oxidative stress and prevent the tumorigenesis of the BCR1 gene | Resveratrol and sulforaphane decrease the ROS accumulation via activation of Nrf2 expression | Hyo et al. [37] |
| MCF-10A, MCF-10F/ HPIMBD, TIMBD | increase the expression of NQO1 and SOD3 and activation of Nrf2 | HPIMBD and TIMBD can prevent breast cancer due to their antioxidant properties | Anwesha et al. [29] | |
| RA-FLS/Res | Nrf2-Keap1 | Overexpression of Nrf2 and reduction in the expression of Keap1, reduction in the ROS and MDA production | Induction of apoptosis through Bcl2, inhibition of cell migration and proliferation, restoring the ROS accumulation caused by H2O2 | Zhang et al. [30] |
| A549/Res | Nrf2-Keap1 | Res loaded in nanoparticles compared to Res showed the better effects in the elevation of Nrf2 level | Activation of Nrf2-Keap1 pathway, restoring the ROS accumulation caused by H2O2 | Kim et al. [20] |
| Animal study in mice/Res | Nrf2/HO-1 pathway | Suppress the IL-8, NF-κB, and iNOS expression and also increase in the HO-1 and Nrf2 | Res can activate the Nrf2/HO-1 pathway | Zhang et al. [38] |
| An animal study in rats with oxidative stress damage in hepatocytes/Res | Increase in the Nrf2 mRNA concentration and antioxidant enzymes (e.g. catalase, glutathione peroxidase, and also superoxide dismutase | Res can protect the hepatocytes in oxidative stress conditions | Rubiolo et al. [39] | |
| HL-60/ effects of Res in a leukemia cell line that is resistant to ADR |
PI3K/Akt/Nrf2 Pathway | PI3K/Akt/Nrf2 expression are decreased in cell line | Res showed the antiproliferative activity against the cell line and promote the inhibition of cells by ADR | Yongjun et al. [25] |
| Human keratinocytes/Res | Nrf2–KEAP1 pathway | Activation of antioxidant in the skin, Increase in the glutathione peroxidase-2, glutamylcysteinyl ligase, and GSH | Res protects the skin cells from oxidative stress | Soeur et al. [32] |
| A375SM/Res | Increase in the p27, and p21 gene expression and reduction of Bcl-2, Nrf2, and cyclin B expression | Res can induce cell cycle arrest and apoptosis and inhibit the cell's proliferation but in contrast, it elevates ROS production and oxidative stress | HEO et al. [33] | |
| Animal study in male Wistar rats with renal carcinoma/ Res + sitagliptin | Nrf2/HO-1 pathway, STAT3/NF-κB signaling | Reduction in the TNF-α, STAT3, LDH, TGF-β1, and IL-6. Res suppress the expression of P-glycoprotein | sitagliptin and Res improve kidney function in rats. They suppress inflammation and oxidative stress and have better effects when they are used together | Kabel et al. [40] |
| HEK293/Res | Increase in the repair enzyme of DNA, OGG1, GSH, and decrease in the expression of Nrf2 | Res has antioxidant and anticancer effects and Increases repair enzymes of DNA, Res can remove the toxicity of OTA | Raghubeer et al. [34] | |
| Pancreatic cancer cell line/Res | ROS/Nrf2 Pathways | Downregulation of NAF-1, induction of ROS accumulation, activation of Nrf2 | Res can inhibit the proliferation and induce apoptosis in cancer cells | Cheng et al. [13] |
| MSTO-211H/combination of Res with clofarabine | PI3K/Akt signaling | Inactivation of Nrf2, suppression of HO-1 | High Inhibitory effects on growth cells when they were used together | Lee et al. [31] |
| oogonial stem cell/Res | Activation of Nrf2 | Res restore the oxidative stress and by chemotherapy in oogonial stem cells. it can reduce the H2O2 and cytotoxicity effects of chemotherapy | Meng et al. [15] |