Nanobodies: a tool to open new horizons in diagnosis and treatment of prostate cancer

Table 1 The nanobodies studied in this paper with diagnostic application against prostate cancer

Name and type of nanobody	Type of application	Binding affinity (Kd)	References
VHH against PSA	Detection	100 nM–70 pM	Saerens et al. [19]
VHH against external domain of PSMA	Detection	10 nM	Evazalipour et al. [8]
VHH against external domain of PSMA	Detection	35 nM	Zare et al. [1]
A radiolabeled (technetium-99 m) nanobody against PSMA	Imaging	36 nM	Evazalipour et al. [4]
technetium-99 m anti-PSMA nanobody	Imaging	4 nM	Evazalipour et al. [4]
111In-radiolabeled anti-PSMA nanobody	Imaging	N/A	Kristell and Chatalic [20]
Nanobody against PSA (cAbPSA-N7)	Biosensor	70 pM	Huang et al. [21]
Nanobody against PSA (cAbPSA-C23)	Biosensor	80 pM	Huang et al. [21]
Nanobodies against PSA	Biosensor	1 nM	Saerens et al. [5]
Nanobodies against PSA	Biosensor	100 pM–10 nM	Liu et al. [6]

ISSN: 1475-2867