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Fig. 3 | Cancer Cell International

Fig. 3

From: Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells

Fig. 3

GO and KEGG pathway analyses of differentially expressed phosphoproteins between the Lob group and the IL-6 group. Three biological replicates were performed for each group. a GO analysis of phosphoproteins differentially regulated in the IL-6 group compared with those in the Lob group. Fisher’s exact test was used. BP: biological process, MF: molecular function, CC: cellular component. The numbers adjacent to each bar are enrichment factors representing the significance and reliability of the phosphoproteins enriched in the term. b Overall level 2 GO enrichment analysis in the biological process, molecular function, and cellular component categories. The left vertical axis shows the numbers of differentially expressed phosphoproteins annotated to a specific term. The right axis shows the percentage of phosphoproteins in the specific item relative to the total number of differentially expressed phosphoproteins. c KEGG pathway analysis showing the signaling pathways up- or downregulated between the IL-6 group and the Lob group. The number adjacent to each bar is the enrichment factor representing the significance of each pathway

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