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Table 2 Enrichment of phosphoproteins and signaling pathways between the IL-6 group and Lob group

From: Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells

Terms

Protein Number

P-value

FDR

Enrich-ment Factor

Phosphoprotein names

GO-UP

     

 BP

     

  Protein localization to plasma membrane

4

0.00116

0.150

8.29

p-filamin-C; p-EH domain-containing protein 2;

p-cytospin-A; p-serine/threonine-protein kinase 26

 MF

  Kinase binding

2

0.0490

0.392

5.58

p-filamin-C; p-shugoshin 1

GO-DOWN

     

 MF

     

  Toll-like receptor

2

0.00216

0.349

27.88

p-caspase-7; p-TNF receptor-associated factor 2

  Hippo signaling

2

0.0212

0.171

8.76

p-caspase-7; p-serine/threonine-protein kinase 26

  Mitogen-activated protein kinase binding

2

0.00583

0.430

17.04

p-serine/threonine-protein kinase 26; p-TNF receptor-associated factor 2

 CC

     

  Inflammasome complex

1

0.0130

0.116

76.66

p-caspase-7

  CD95 death-inducing signaling complex

1

0.0194

0.171

51.11

p-caspase-7

  Gap junction

1

0.0258

0.210

38.33

p-cytospin-A

KEGG pathways

     

 TNF signaling pathway

2

0.0190

0.186

9.29

p-caspase-7; p-TNF receptor-associated factor 2

 NOD-like receptor signaling pathway

2

0.0260

0.394

7.86

p-TP53-binding protein 1; p-TNF receptor-associated factor 2

 Apoptosis

2

0.0326

0.186

6.97

p-caspase-7; p-TNF receptor-associated factor 2

 MAPK signaling pathway

2

0.0808

0.289

4.20

p-filamin-C; p-TNF receptor-associated factor 2

  1. BP biological processes, MF molecular functions, CC cellular components, FDR false discovery rate
  2. GO and KEGG pathway enrichment results were analyzed with Fisher’s exact test, and p < 0.05 was considered significant