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Table 2 Enrichment of phosphoproteins and signaling pathways between the IL-6 group and Lob group

From: Quantitative phosphoproteomic analysis reveals chemoresistance-related proteins and signaling pathways induced by rhIL-6 in human osteosarcoma cells

Terms Protein Number P-value FDR Enrich-ment Factor Phosphoprotein names
GO-UP      
 BP      
  Protein localization to plasma membrane 4 0.00116 0.150 8.29 p-filamin-C; p-EH domain-containing protein 2;
p-cytospin-A; p-serine/threonine-protein kinase 26
 MF
  Kinase binding 2 0.0490 0.392 5.58 p-filamin-C; p-shugoshin 1
GO-DOWN      
 MF      
  Toll-like receptor 2 0.00216 0.349 27.88 p-caspase-7; p-TNF receptor-associated factor 2
  Hippo signaling 2 0.0212 0.171 8.76 p-caspase-7; p-serine/threonine-protein kinase 26
  Mitogen-activated protein kinase binding 2 0.00583 0.430 17.04 p-serine/threonine-protein kinase 26; p-TNF receptor-associated factor 2
 CC      
  Inflammasome complex 1 0.0130 0.116 76.66 p-caspase-7
  CD95 death-inducing signaling complex 1 0.0194 0.171 51.11 p-caspase-7
  Gap junction 1 0.0258 0.210 38.33 p-cytospin-A
KEGG pathways      
 TNF signaling pathway 2 0.0190 0.186 9.29 p-caspase-7; p-TNF receptor-associated factor 2
 NOD-like receptor signaling pathway 2 0.0260 0.394 7.86 p-TP53-binding protein 1; p-TNF receptor-associated factor 2
 Apoptosis 2 0.0326 0.186 6.97 p-caspase-7; p-TNF receptor-associated factor 2
 MAPK signaling pathway 2 0.0808 0.289 4.20 p-filamin-C; p-TNF receptor-associated factor 2
  1. BP biological processes, MF molecular functions, CC cellular components, FDR false discovery rate
  2. GO and KEGG pathway enrichment results were analyzed with Fisher’s exact test, and p < 0.05 was considered significant