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Fig. 9 | Cancer Cell International

Fig. 9

From: Circ-RNF121 regulates tumor progression and glucose metabolism by miR-1224-5p/FOXM1 axis in colorectal cancer

Fig. 9

Extracellular circ-RNF121 was secreted by being packaged into exosomes in CRC cells. A TEM was performed to identify the structure of extracted vesicles. B Western blot was carried out to detect the expression levels of CD63 and CD81 in the extracted vesicles and cell extracts. C The expression of circ-RNF121 was determined by qRT-PCR in these exosomes from NCM460, HCT-116 and SW480 cells. D Circ-RNF121 expression in these exosomes isolated from HCT-116 and SW480 cells treated with GW4869(+) or GW4869(−) was determined by qRT-PCR. Exo-circ-RNF121: the circ-RNF121 derived from exosomes. GW4869(+): both HCT-116 and SW480 cells were treated with GW4869; GW4869(−): both HCT-116 and SW480 cells were not treated with GW4869. ***P  < 0.001 and ****P  < 0.0001

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