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Fig. 3 | Cancer Cell International

Fig. 3

From: Lactate induces aberration in the miR-30a–DBF4 axis to promote the development of gastric cancer and weakens the sensitivity to 5-Fu

Fig. 3

DBF4 weakens the sensitivity of MGC803 and AGS cells to 5-Fu. MGC803 and AGS cells were transfected with plasmid or siRNA for DBF4 (DBF4 or siDBF4) for 24 h. MGC803, AGS cells (A), DBF4-overexpressing MGC803-DBF4, AGS-DBF4 cells (B) and MGC803-siDBF4, AGS-siDBF4 cells (C) were incubated with control medium or various concentrations of 5-Fu as indicated at 37℃ for 48 h. After incubation, cell viability was measured by a CCK-8 assay. D Analysis for the IC50 of 5-Fu in treated cells. Results are expressed as percent of control and represent the mean±SD

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Cancer Cell International

ISSN: 1475-2867

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