Skip to main content
Fig. 6 | Cancer Cell International

Fig. 6

From: Lactate induces aberration in the miR-30a–DBF4 axis to promote the development of gastric cancer and weakens the sensitivity to 5-Fu

Fig. 6

Overexpression of DBF4 restores the effects of miR-30a upregulation on GC cells. MGC-803 and AGS cells were transfected with miR-NC, miR-30a, miR-30a+PEX, or miR-30a+PEX-DBF4. A qRT-PCR analysis was used to determine DBF4 mRNA expression levels in MGC-803 (above) and AGS (below) cells. B, C The proliferation of MGC-803 and AGS cells was assessed using CCK-8 (B) and colony formation (C) assays. Transwell assay (D) and wound healing assay (E) were performed to detect the migration of gastric cancer cells. F The IC 50 of 5-Fu in the two GC cells introduced with miR-NC, miR-30a, miR-30a+PEX, or miR-30a+PEX-DBF4. Data are presented as the mean ± SD (n = 3). **P < 0.01

Back to article page

Cancer Cell International

ISSN: 1475-2867

Contact us