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Table 1 The expression of SNHG4 and its clinical significance in a variety of diseases

From: Long noncoding RNA SNHG4: a novel target in human diseases

Disease type Number of clinical samples Expression level Clinicopathologic features HR P value Prognostic implication of SNHG4 overexpression Property PMID
Gastric cancer (GC) 53 tissue samples from GC patients Upregulation Lymph node metastasis, tumour invasion, TNM stage 1.54 P < 0.001 Poor Oncogene 33236157
Renal cell carcinoma (RCC) 99 pairs of RCC tissues and adjacent normal tissues Upregulation Advanced T stage, node invasion, distant metastasis status, poor tumour grade, relapse status 1.50 P = 0.007 Poor Oncogene 33088220
Glioblastoma (GBM) 62 pairs of GBM tissues and adjacent normal tissues Upregulation 3.32 Poor Oncogene 32427712
Neuroblastoma 30 pairs of neuroblastoma tissues and adjacent normal tissues Upregulation P = 0.018 Poor Oncogene 32614236
Prostate cancer (PCa) 113 pairs of PC tissues and adjacent normal tissues Upregulation Tumour stage, lymph node metastasis P = 0.005 Poor Oncogene 31608997
Colorectal cancer (CRC) 12 pairs of CRC tissues and adjacent normal tissues Upregulation Oncogene 33744866
Osteosarcoma 24 pairs of osteosarcoma tissues and adjacent normal tissues Upregulation Distant metastasis, lager tumour size, advanced pathological stage P = 0.047 Poor Oncogene 32537941
136 cases of osteosarcoma patients and 40 adjacent normal tissue Upregulation Tumour size P = 0.001 Poor Oncogene 30152090
Cervical cancer (CC) 27 pairs of CC tissues and adjacent normal tissues Upregulation Oncogene 31590627
Liver cancer 371 liver cancer tissues and 50 normal liver tissues Upregulation Histological type, histologic grade, stage, T classification, survival status P < 0.001 Poor Oncogene 31967298
Hepatocellular carcinoma (HCC) 49 pairs of HCC tissues and adjacent normal tissues Upregulation P < 0.001 Poor Oncogene 30537372
Non-small-cell lung cancer (NSCLC) 50 pairs of NSCLC tissues and adjacent normal tissues Upregulation Poor Oncogene 33816782
Neonatal pneumonia (NP) 15 peripheral venous blood from NP patients and healthy controls Downregulation 34450538
Diabetic retinopathy (DR) 60 tissue samples from DR patients, diabetic patients without complication and healthy controls Downregulation 32454787
Acute cerebral infarction (ACI) 30 tissue samples from ACI patients and healthy controls Downregulation 32982175
Acute myeloid leukaemia (AML) 60 tissue samples from AML patients and healthy controls Downregulation 32319862
Endometriosis 25 EC samples and EU samples Upregulation 32525017
  1. EC, ectopic endometrium; EU, eutopic endometrium