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Table 2 Function and mechanism of SNHG4 in different diseases

From: Long noncoding RNA SNHG4: a novel target in human diseases

Disease type Cell lines Expression level Effect in vitro Effect in vivo Genes/proteins/pathways affected PMID
Gastric cancer (GC) GES-1, AGS, HGC-27, NCI-N87, MKN-45, 293T Upregulation Proliferation ↑, migration ↑, invasion ↑, cell cycle arrest ↓ Tumour growth ↑ miR-204-5p, RRM2 33567852
GES-1, SNU719, AGS, HGC-27 Upregulation Proliferation ↑, migration ↑, invasion ↑, EMT ↑, apoptosis ↓ miR-204-5p 33236157
Renal cell carcinoma (RCC) Caki-1, Caki-2, ACHN, 786-O, 769-P, HK-2 Upregulation Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ Tumour growth ↑ miR-204-5p, RUNX2 33088220
Glioblastoma (GBM) U-251 Upregulation Proliferation ↑ miR-138, c-Met axis 32427712
Neuroblastoma SH-SY5Y, CHP-212, SK-N-FI, and IMR-32, 293T Upregulation Proliferation ↑, migration ↑, invasion ↑, EMT ↑, apoptosis ↓ Tumour growth ↑ lung metastasis ↑ miR-377-3p 32614236
Prostate cancer (PCa) PC-3, LNCaP, DU145, 22RV1, WPMY-1 Upregulation Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ miR‐377, ZIC5 31608997
Colorectal cancer (CRC) FHC, HCT8, LoVo, HCT116, SW620, HT29 Upregulation Proliferation ↑, migration ↑, invasion ↑, cell cycle arrest ↓ Tumour growth ↑ miR-590-3p, CDK1 33744866
Osteosarcoma hFOB1.19, HOS, MG63, Saos2, SJSA1, U2OS Upregulation Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ Tumour growth ↑ miR-377-3p 32537941
MG-63, HOS, 143B, SW-1353, Saos2, U2OS Upregulation Proliferation ↑, colony formation ↑ miR-224- 3p 30152090
Cervical cancer (CC) NCEC, c4-1, Caski, HeLa, SiHa Upregulation Proliferation ↑, apoptosis ↓ Tumour growth ↑ miR-148a-3p, c-Met 31590627
Lung cancer NCI-H2170, NCI-H520, SK-MES-1, NCI-H1975, NCI-H1437, SPC-A-1 Upregulation Proliferation ↑, migration ↑, invasion ↑, EMT ↑, cell cycle arrest ↓ Tumour growth ↑ miR-98-5p 31220419
Non-small-cell lung cancer (NSCLC) H1299, H1650, H1975, SPCA1, 16HBE Upregulation Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ Tumour growth ↑ miR-let-7e, KDM3A, p21 33816782
Neonatal pneumonia (NP) WI-38 Downregulation Proliferation ↑, migration ↑, SOD concentration ↑, Inflammation ↓, apoptosis ↓ METTL3, NF-κB pathway 34450538
Diabetic retinopathy (DR) ARPE-19 Downregulation Apoptosis ↓ miR-200b, Oxr1 33822671
Neuropathic pain PC12 Upregulation Inflammation ↑ miR-423-5p 32454787
Acute cerebral infarction (ACI) HAPI, HEK293 Downregulation Inflammation ↓ miR-449c-5p, STAT6 32982175
Acute myeloid leukaemia (AML) Kasumi-6 Downregulation Proliferation ↓ miR-10a, PTEN 32319862
Endometriosis HESCs Upregulation Proliferation ↑ Endometrial tissue growth ↑ miR-148a-3p, c-Met 32525017