Table 2 Function and mechanism of SNHG4 in different diseases
From: Long noncoding RNA SNHG4: a novel target in human diseases
Disease type | Cell lines | Expression level | Effect in vitro | Effect in vivo | Genes/proteins/pathways affected | PMID |
|---|---|---|---|---|---|---|
Gastric cancer (GC) | GES-1, AGS, HGC-27, NCI-N87, MKN-45, 293T | Upregulation | Proliferation ↑, migration ↑, invasion ↑, cell cycle arrest ↓ | Tumour growth ↑ | miR-204-5p, RRM2 | 33567852 |
GES-1, SNU719, AGS, HGC-27 | Upregulation | Proliferation ↑, migration ↑, invasion ↑, EMT ↑, apoptosis ↓ | – | miR-204-5p | 33236157 | |
Renal cell carcinoma (RCC) | Caki-1, Caki-2, ACHN, 786-O, 769-P, HK-2 | Upregulation | Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ | Tumour growth ↑ | miR-204-5p, RUNX2 | 33088220 |
Glioblastoma (GBM) | U-251 | Upregulation | Proliferation ↑ | – | miR-138, c-Met axis | 32427712 |
Neuroblastoma | SH-SY5Y, CHP-212, SK-N-FI, and IMR-32, 293T | Upregulation | Proliferation ↑, migration ↑, invasion ↑, EMT ↑, apoptosis ↓ | Tumour growth ↑ lung metastasis ↑ | miR-377-3p | 32614236 |
Prostate cancer (PCa) | PC-3, LNCaP, DU145, 22RV1, WPMY-1 | Upregulation | Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ | – | miR‐377, ZIC5 | 31608997 |
Colorectal cancer (CRC) | FHC, HCT8, LoVo, HCT116, SW620, HT29 | Upregulation | Proliferation ↑, migration ↑, invasion ↑, cell cycle arrest ↓ | Tumour growth ↑ | miR-590-3p, CDK1 | 33744866 |
Osteosarcoma | hFOB1.19, HOS, MG63, Saos2, SJSA1, U2OS | Upregulation | Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ | Tumour growth ↑ | miR-377-3p | 32537941 |
MG-63, HOS, 143B, SW-1353, Saos2, U2OS | Upregulation | Proliferation ↑, colony formation ↑ | – | miR-224- 3p | 30152090 | |
Cervical cancer (CC) | NCEC, c4-1, Caski, HeLa, SiHa | Upregulation | Proliferation ↑, apoptosis ↓ | Tumour growth ↑ | miR-148a-3p, c-Met | 31590627 |
Lung cancer | NCI-H2170, NCI-H520, SK-MES-1, NCI-H1975, NCI-H1437, SPC-A-1 | Upregulation | Proliferation ↑, migration ↑, invasion ↑, EMT ↑, cell cycle arrest ↓ | Tumour growth ↑ | miR-98-5p | 31220419 |
Non-small-cell lung cancer (NSCLC) | H1299, H1650, H1975, SPCA1, 16HBE | Upregulation | Proliferation ↑, migration ↑, invasion ↑, apoptosis ↓ | Tumour growth ↑ | miR-let-7e, KDM3A, p21 | 33816782 |
Neonatal pneumonia (NP) | WI-38 | Downregulation | Proliferation ↑, migration ↑, SOD concentration ↑, Inflammation ↓, apoptosis ↓ | – | METTL3, NF-κB pathway | 34450538 |
Diabetic retinopathy (DR) | ARPE-19 | Downregulation | Apoptosis ↓ | – | miR-200b, Oxr1 | 33822671 |
Neuropathic pain | PC12 | Upregulation | Inflammation ↑ | – | miR-423-5p | 32454787 |
Acute cerebral infarction (ACI) | HAPI, HEK293 | Downregulation | Inflammation ↓ | – | miR-449c-5p, STAT6 | 32982175 |
Acute myeloid leukaemia (AML) | Kasumi-6 | Downregulation | Proliferation ↓ | – | miR-10a, PTEN | 32319862 |
Endometriosis | HESCs | Upregulation | Proliferation ↑ | Endometrial tissue growth ↑ | miR-148a-3p, c-Met | 32525017 |