Table 1 The relationship between PD-1 expression and malignancy
Parameter | PD-1 expression rate of CD8+ TILs | ||
|---|---|---|---|
Low PD-1 CD8+ (%) (< 17.5) N = 46 | High PD-1 CD8+ (%) (> 17.5) N = 25 | P-value | |
Age (years) | |||
< 60 | 15 (32) | 9 (36) | 0.592 |
≥ 60 | 31 (68) | 14 (64) | |
Gender | |||
Male | 44 (95) | 24 (96) | 0.944 |
Female | 2 (5) | 1 (4) | |
Differentiation | |||
High differentiation | 18 (39) | 7 (28) | 0.348 |
Poor differentiation | 28 (61) | 18 (72) | |
Tumor size(cm) | |||
≤ 2 | 16 (34) | 6 (24) | 0.348 |
> 2 | 30 (66) | 19 (76) | |
Clinical stage | |||
I–II | 21 (45) | 4 (16) | 0.01* |
III–IV | 25 (55) | 21 (84) | |
Lymph node metastasis | 0.007** | ||
Negative | 30 (65) | 8 (32) | |
Positive | 16 (35) | 17 (68) | |