Table 2 Unadjusted and multivariate analyses for overall survival (3-category stroma-immune score)
Development group | Internal validation group | External validation group | |||||||
|---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
Unadjusted stratified Cox model | |||||||||
Stroma-immune score | |||||||||
Low | 1 | 1 | 1 | ||||||
Intermediate | 0.48 | 0.27–0.84 | 0.011 | 0.60 | 0.30–1.18 | 0.140 | 0.31 | 0.10–0.94 | 0.039 |
High | 0.30 | 0.16–0.58 | < 0.001 | 0.40 | 0.19–0.85 | 0.017 | 0.40 | 0.13–1.22 | 0.110 |
Multivariable stratified Cox model | |||||||||
Stroma-immune score | |||||||||
Low | 1 | 1 | 1 | ||||||
Intermediate | 0.45 | 0.25–0.79 | 0.006 | 0.60 | 0.30–1.19 | 0.15 | 0.34 | 0.11–1.06 | 0.062 |
High | 0.35 | 0.18–0.66 | 0.001 | 0.43 | 0.20–0.92 | 0.029 | 0.40 | 0.13–1.23 | 0.110 |
TNM stage | |||||||||
II | 1 | 1 | 1 | ||||||
III | 3.25 | 1.76–6.00 | < 0.001 | 2.63 | 1.40–4.95 | 0.003 | 1.77 | 0.75–4.20 | 0.195 |
Age | 1.04 | 1.01–1.06 | 0.007 | 1.02 | 0.99–1.04 | 0.15 | 1.03 | 1.00–1.07 | 0.072 |