From: Mesenchymal stem cells in cancer progression and anticancer therapeutic resistance
Molecules | Functions | Cancer types | References |
---|---|---|---|
IL-2 | Delaying tumor growth and developing CD8-mediated tumor-specific anticancer immunity | Melanoma | [114] |
IL-12 | Boosting antitumor T cell responses and inhibiting tumor growth | Melanoma; cervical cancer | [113] |
IL-18 | Activating T cells | GBM | [143] |
NK4 | Inhibiting angiogenesis and promoting apoptosis | Lung cancer | [144] |
IFN-β | Inhibiting the growth of cancer cells | Melanoma; metastatic prostate cancer | |
IFN-γ | Immunostimulation and stimulating apoptosis | Leukemia | [146] |
CX3CL1 | Activating CD8+ and NK cells | Lung cancer | [147] |
PE-cytotoxins | – | GBM | [148] |
sFlt-1 | Inhibiting angiogenesis and metastasis | Tumor lung metastasis | [149] |
iNOS | Inhibiting growth of tumor cells | Fibrosarcoma | [150] |
HSV-TK | Transferring ganciclovir into active cytotoxic drugs | GBM | [112] |
Nanoparticle | Drug-loaded polymeric nanoparticles | Lung cancer | [83] |
TRAIL | Inducing apoptosis | Lung cancer | [82] |
Cytosine deaminase | Converting inactive systemically administered prodrugs into active cytotoxic agents | Colon cancer; prostate cancer | |
rCE | Converting the CPT-11 to SN-38 | GBM | [151] |
miR-124a | Decreasing survival of cancer cells | GBM | [152] |
miR-143 | Inhibiting cancer migration | Osteosarcoma | [153] |
miR-146b | Inhibiting cancer cells growth | GBM | [154] |
Cytotoxic chemotherapy agents | Inhibiting cell viability and reducing cancer cell growth | Oral squamous cancer | [128] |
miR-193a | Reducing cisplatin resistance of NSCLC cells by downregulating LRRC1 | NSCLC | [131] |
anti-miR-9 | Reversing the chemoresistance of GBM cells to TMZ by regulating the expression of multidrug transporter | GBM | [132] |
siGRP78 | Reversing the drug resistance | HCC | [133] |
miR-122 | Enhancing cancer cells chemosensitivity to sorafenib by downregulating the expression of CCNG1, ADAM10 and IGF1R | HCC | [134] |
MiR-6785-5p | Suppressing angiogenesis and metastasis in GC | GC | [155] |