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Fig. 3 | Cancer Cell International

Fig. 3

From: Hexokinases 2 promoted cell motility and distant metastasis by elevating fibronectin through Akt1/p-Akt1 in cervical cancer cells

Fig. 3

HK2 overexpression induces FN1 expression and activates Akt1/p-Akt1. A Heatmap of the enriched differentially expressed genes in the PI3K/Akt signaling pathway identified by GO enrichment analysis of RNA transcriptome sequencing data from HeLa-HK2 and HeLa-Vec cells; data were log10 normalized. B The mRNA expression of FN1 was detected by real-time quantitative PCR, and the quantitative analysis is shown: B HeLa-Vec and HeLa-HK2 cells; C SiHa-Vec and SiHa-HK2 cells; D HeLa-shControl and HeLa-shHK2 cells. E SiHa-shControl and SiHa-shHK2 cells. The protein levels of HK2, Akt1, p-Akt1, FN1, MMP2 and MMP9 were detected by western blotting, and the quantitative analysis is shown: F HeLa-Vec and HeLa-HK2 cells; G SiHa-Vec and SiHa-HK2 cells; H HeLa-shControl and HeLa-shHK2 cells; I SiHa-shControl and SiHa-shHK2 cells. The data are shown as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01 vs. control using one-way ANOVA

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