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Fig. 5 | Cancer Cell International

Fig. 5

From: Comprehensive analysis of CXCL12 expression reveals the significance of inflammatory fibroblasts in bladder cancer carcinogenesis and progression

Fig. 5

CXCL12 correlated with the TME of BLCA that influenced patients' responsiveness to ICB therapy. A, B CXCL12 is positively correlated with immune checkpoint genes, including PDCD1, PDCD1LG2, CD274, CTLA4, TIGIT, LAG3, and HAVCR2, but negatively related to SIGLEC15. C, D The MCP-COUNTER algorithm indicated that CXCL12 expression level is positively associated with CD8 + T cells, endothelial cells and CAFs in the TME. E The ESTIMATE algorithm showed a positive correlation of CXCL12 expression with the stromal and immune scores. F, G CXCL12 was associated with patients' age, SASP and aging-related genes. H The TIDE algorithm demonstrated that CXCL12 expression influenced the responsiveness of BLCA patients to ICB therapy. *** p < 0.001, ns: not significant

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Cancer Cell International

ISSN: 1475-2867

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