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Fig. 8 | Cancer Cell International

Fig. 8

From: Comprehensive analysis of CXCL12 expression reveals the significance of inflammatory fibroblasts in bladder cancer carcinogenesis and progression

Fig. 8

IHC verification of the association of CXCL12 and iCAFs with CD8 + cells infiltration. A Intratumoral CD8 + T cells were observed in tumors with negative stromal CXCL12 and PDGFRA expression. B Significant infiltration of CD8 + T cells was found in the stromal components of CXCL12 and PDGFRA positive tumors, highlighting the exclusion of CD8 + T cells by iCAFs. C Statistics analysis indicated a significant decrease of intratumoral CD8 T cells in iCAFs positive tumors. D CXCL12 expression was expressed by endothelial cells and iCAFs in BLCA and was upregulated in MIBC. E PDGFRA was mainly expressed by iCAFs in BLCA, upregulated in MIBC. F The IMvigor210 cohort confirmed the iCAFs score was correlated with patients' responsiveness to ICB therapy. *** p < 0.001

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Cancer Cell International

ISSN: 1475-2867

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