Fig. 1
From: A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
A schematic diagram showing the structure and transcription regulators of sestrin 2. A The functional domains of human sestrin 2 (sestrin-A, sestrin-B, and sestrin-C). In sestrin-A, the cysteine residue (C125) and conserved residues of the proton relay system (Y127 and H132) are important for its antioxidant activity. In sestrin-C, the two surface-exposed aspartates (D406 and D407, DD motif) are responsible for interacting with GATOR2 to inhibit mTORC1 signaling. B Sestrin2 expression plays a central role in cancer regulated by multiple transcription factors and miRNAs