From: A paradoxical role for sestrin 2 protein in tumor suppression and tumorigenesis
Tumor | Cell type/model | Sestrin2 expression | Biological function of Sestrin2 | Mechanism | References | |
---|---|---|---|---|---|---|
CRC | CRC patients:279 | Down | Suppressor gene | Suppresses tumor invasion and metastasis | N/A | [30] |
Human CRC cells (HT-29, SW480, SW620 and LoVo) | Prognostic factor for CRC | |||||
A mouse xenograft model | Suppresses CRC xenografts growth | |||||
CRC | Oncomine analysis | Down | Suppressor gene | Inhibits colitis and colon carcinogenesis | Inhibited ER stress and mTORC1 | [33] |
SGC | Eyelid SGC tumour:20 | Down | Suppressor gene | Correlate with tumor differentiation and upper eyelid involvement | N/A | [34] |
NB | 50 NB (GEO ID: GSE12460) | Down | N/A | Correlate with prognosis | Through Sestrin2/mTORC1 pathway | [35] |
Participates in the regulation of autophagy by LSD1 | ||||||
Bladder cancer | Bladder cancer patients:10 | Down | Suppressor gene | Participates in isorhapontigenin-induced autophagy | Via a MAPK8-JUN-Sestrin2-dependent manner | [36] |
Prostate cancer | Prostate cancer cells (LNCaP clone FGC, DU145, PC3) | Down | Suppressor gene | Inhibits cell proliferation and increases radiosensitization | N/A | [37] |
SCC and Melanoma | SCC, malignant melanoma, and metastatic melanoma samples | Up | Oncogene | Inhibits apoptosis, induces drug resistance | Activates AKT through a PTEN dependent manner | [38] |
Human squamous carcinoma cell (A431), human amelanotic melanoma cells (A375, MEL624) | ||||||
A431, A375/xenograft tumor model | ||||||
Metastatic melanoma | Metastatic melanoma tissue microarray: 45 | Up | Oncogene | Serve as a predictor of poor prognosis | Reduces intracellular ROS | [39] |
Metastatic melanoma cells (A375, A2058, UACC257,451Lu and HTB67) | Promotes anoikis resistance and distant metastasis | |||||
A2058/xenograft tumor model | ||||||
EC | Endometrial cancer: 6 | Up | N/A | Relates to the overall survival and disease-free survival | Dependent on the mTORC1 pathway | [40] |
UCEC and the Human Protein Atlas database | ||||||
Human endometrial adenocarcinoma cells (HEC-1A, Ishikawa) | Inhibits proliferation, migration and ROS production | |||||
HEC-1A/xenograft tumor model | suppresses tumor growth | |||||
NSCLC | NSCLC patients:210 | Down | Suppressor gene | Associates with tumor differentiation, advanced TNM stage, lymph node metastasis and overall survival; a favorable prognostic factor | N/A | [42] |
Lung cancer | Lung cancer patients:77 | Down:57 Up:20 | suppressor gene | The low expression level of Sestrin2 associates with the poor survival | Suppresses Akt-mTOR-p70S6K signaling pathway | [43] |
Human lung adenocarcinoma cell (A549); human bronchial epithelial cell (BEAS-2B) | Suppresses the cell proliferation, migration, malignant transformation | |||||
BEAS-2B cell/xenograft tumor model | Suppresses the xenograft tumor growth in nude mice | |||||
Lung cancer | Oncomine and the Human Protein Atlas database | Up | Oncogene | Overexpressed Sestrin2 has a poor prognostic value | N/A | [44] |
Human lung adenocarcinoma cell (A549) | Promotes cell proliferation, migration, sphere formation, and drug resistance | |||||
Lung cancer | GEO (GSE 11969) and TCGA database | Up | Oncogene | The low expression of Sestrin2 showed longer survival | N/A | [45] |
HCC | HCC patients:15 | Down | suppressor gene | Associates with HBV/HCV infection, lymph node metastasis, tumor progression, and poor prognosis | N/A | [48] |
HCC | HCC patients:14 | Down | N/A | Participates in muscone-induced apoptosis and autophagy | Promotes cell apoptosis by PERK /ATF4/DDIT3 mediated ER stress; induces autophagy by Sestrin2/AMPK/mTORC1 pathway | [49] |
HCC | HCC patients:30 | Up | Oncogene | Correlates with proliferation marker Ki-67 | Activates AKT and AMPK pathways | [31] |
HCC cell lines (Bel‐7404, HLF, HLE, SNU‐368, and Hep3B) | promotes cell proliferation and sorafenib resistance, inhibits apoptosis |