Table 1 The role of m6A regulators in ovarian cancer
Regulators | Functions | Upregulated/downregulated in OC | References |
|---|---|---|---|
YTHDF1 | YTHDF1-eIF3C axis | Upregulated | [63] |
YTHDF2 | Inhibits the expression of miR-145 | Upregulated | [62] |
IGF2BP1 | Affects classical oncogenes; promotes SRF expression; participates in Wnt/β-catenin signaling pathway | Upregulated | |
METTL3 | Stimulates AXL translation and EMT; participates in AKT signaling pathway | Upregulated | |
ALKBH5 | Activates NF-κB pathway; regulates autophagy initiation; regulates the content of metabolites | Upregulated | |
FTO | Inhibits stemness characteristics; inhibits the hydrolysis of second messenger cAMP | Downregulated | |
WTAP | Associated with the worst overall survival (OS); relates to the regulation of the cell cycle and the target of MYC | Upregulated | [60] |
FZD10 | Upregulates the Wnt/β-catenin pathway and HR DNA repair activity in BRCA1/2 mutant ovarian cancer cells | Upregulated |