Fig. 1

A The workflow of the study. B and C Results of the clustering algorithm and the integrated clusters with K = 3. D Differences in SNV scores among three original integrated clusters (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, ns means no statistical significance, according to two independent samples with a Wilcox test). E, KM curve analysis of the three original integrated clusters