Fig. 8

The repression of the EGFR/PI3K/AKT pathway impair the ability of proliferation and metastasis in PTC cell. Overexpression of mir-30b-5p inhibits tumor progression in vivo. A The relative fold changes of EdU positive cells were detected with pcDNA-GALNT7 or BMS-599626. B, C The relative fold changes of invasion and migration cells were detected pcDNA-GALNT7 or BMS-599626. D, E Overexpression of mir-30b-5p inhibited the growth of transplanted B-CPAP cell in nude mice. F, G Immunohistochemistry and Western Blot were used to detect the expression after miRNA agomir was injected into mice. Data are presented as the mean ± SD (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001)