Table 1 Correlation of NEDD4L expression with clinic-pathologic characteristics in AML
Patient’s parameters | NEDD4L expression | ||
|---|---|---|---|
Low (n = 87) | High (n = 86) | P value | |
Sex, male/female | 48/39 | 44/42 | 0.353 |
Median age, years (range) | 55 (21–77) | 61 (18–88) | 0.017 |
Median WBC, × 109/L (range) | 31.5 (0.9–223.8) | 8.6 (0.4–297.4) | 0.000 |
Median PB blasts, % (range) | 50 (0–97) | 22 (0–98) | 0.002 |
Median BM blasts, % (range) | 76 (32–100) | 62.5 (30–99) | 0.005 |
FAB classifications | Â | Â | 0.124 |
 M0 | 7 | 9 | 0.611 |
 M1 | 21 | 23 | 0.729 |
 M2 | 22 | 16 | 0.359 |
 M3 | 11 | 5 | 0.188 |
 M4 | 13 | 21 | 0.130 |
 M5 | 12 | 6 | 0.212 |
 M6 | 0 | 2 | 0.246 |
 M7 | 0 | 3 | 0.121 |
 No data | 1 | 0 | 1.000 |
Cytogenetics | Â | Â | 0.000 |
 Normal | 51 | 29 | 0.001 |
 t (15;17) | 10 | 5 | 0.280 |
 t (8;21) | 6 | 1 | 0.117 |
 Inv (16) | 3 | 7 | 0.211 |
 + 8 | 3 | 5 | 0.496 |
 Del (5) | 0 | 1 | 1.000 |
 −7/del (7) | 2 | 5 | 0.278 |
 11q23 | 2 | 1 | 1.000 |
 Others | 3 | 11 | 0.028 |
 Complex | 5 | 20 | 0.001 |
 No data | 2 | 1 | 1.000 |
Gene mutation | |||
 FLT3 (±) | 33/54 | 16/70 | 0.007 |
 NPM1 (±) | 34/53 | 14/72 | 0.001 |
 DNMT3A (±) | 27/60 | 15/71 | 0.051 |
 IDH2 (±) | 9/78 | 8/78 | 1.000 |
 IDH1 (±) | 8/79 | 8/78 | 1.000 |
 TET2 (±) | 4/83 | 11/75 | 0.063 |
 RUNX1 (±) | 10/77 | 14/72 | 0.388 |
 TP53 (±) | 2/85 | 12/74 | 0.005 |
 NRAS (±) | 5/82 | 7/79 | 0.566 |
 CEBPA (±) | 7/80 | 6/80 | 1.000 |
 WT1 (±) | 7/80 | 3/83 | 0.329 |
 PTPN11 (±) | 4/83 | 4/82 | 1.000 |
 KIT (±) | 3/84 | 4/82 | 0.720 |
 U2AF1 (±) | 1/86 | 6/80 | 0.064 |
 KRAS (±) | 4/83 | 3/83 | 1.000 |