|
Sex, male/female
|
48/39
|
44/42
|
0.353
|
|
Median age, years (range)
|
55 (21–77)
|
61 (18–88)
|
0.017
|
|
Median WBC, × 109/L (range)
|
31.5 (0.9–223.8)
|
8.6 (0.4–297.4)
|
0.000
|
|
Median PB blasts, % (range)
|
50 (0–97)
|
22 (0–98)
|
0.002
|
|
Median BM blasts, % (range)
|
76 (32–100)
|
62.5 (30–99)
|
0.005
|
|
FAB classifications
| | |
0.124
|
|
M0
|
7
|
9
|
0.611
|
|
M1
|
21
|
23
|
0.729
|
|
M2
|
22
|
16
|
0.359
|
|
M3
|
11
|
5
|
0.188
|
|
M4
|
13
|
21
|
0.130
|
|
M5
|
12
|
6
|
0.212
|
|
M6
|
0
|
2
|
0.246
|
|
M7
|
0
|
3
|
0.121
|
|
No data
|
1
|
0
|
1.000
|
|
Cytogenetics
| | |
0.000
|
|
Normal
|
51
|
29
|
0.001
|
|
t (15;17)
|
10
|
5
|
0.280
|
|
t (8;21)
|
6
|
1
|
0.117
|
|
Inv (16)
|
3
|
7
|
0.211
|
|
+ 8
|
3
|
5
|
0.496
|
|
Del (5)
|
0
|
1
|
1.000
|
|
−7/del (7)
|
2
|
5
|
0.278
|
|
11q23
|
2
|
1
|
1.000
|
|
Others
|
3
|
11
|
0.028
|
|
Complex
|
5
|
20
|
0.001
|
|
No data
|
2
|
1
|
1.000
|
|
Gene mutation
|
|
FLT3 (±)
|
33/54
|
16/70
|
0.007
|
|
NPM1 (±)
|
34/53
|
14/72
|
0.001
|
|
DNMT3A (±)
|
27/60
|
15/71
|
0.051
|
|
IDH2 (±)
|
9/78
|
8/78
|
1.000
|
|
IDH1 (±)
|
8/79
|
8/78
|
1.000
|
|
TET2 (±)
|
4/83
|
11/75
|
0.063
|
|
RUNX1 (±)
|
10/77
|
14/72
|
0.388
|
|
TP53 (±)
|
2/85
|
12/74
|
0.005
|
|
NRAS (±)
|
5/82
|
7/79
|
0.566
|
|
CEBPA (±)
|
7/80
|
6/80
|
1.000
|
|
WT1 (±)
|
7/80
|
3/83
|
0.329
|
|
PTPN11 (±)
|
4/83
|
4/82
|
1.000
|
|
KIT (±)
|
3/84
|
4/82
|
0.720
|
|
U2AF1 (±)
|
1/86
|
6/80
|
0.064
|
|
KRAS (±)
|
4/83
|
3/83
|
1.000
|
