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Table 1 Correlation of NEDD4L expression with clinic-pathologic characteristics in AML

From: Distinct associations of NEDD4L expression with genetic abnormalities and prognosis in acute myeloid leukemia

Patient’s parameters NEDD4L expression
Low (n = 87) High (n = 86) P value
Sex, male/female 48/39 44/42 0.353
Median age, years (range) 55 (21–77) 61 (18–88) 0.017
Median WBC, × 109/L (range) 31.5 (0.9–223.8) 8.6 (0.4–297.4) 0.000
Median PB blasts, % (range) 50 (0–97) 22 (0–98) 0.002
Median BM blasts, % (range) 76 (32–100) 62.5 (30–99) 0.005
FAB classifications    0.124
 M0 7 9 0.611
 M1 21 23 0.729
 M2 22 16 0.359
 M3 11 5 0.188
 M4 13 21 0.130
 M5 12 6 0.212
 M6 0 2 0.246
 M7 0 3 0.121
 No data 1 0 1.000
Cytogenetics    0.000
 Normal 51 29 0.001
 t (15;17) 10 5 0.280
 t (8;21) 6 1 0.117
 Inv (16) 3 7 0.211
 + 8 3 5 0.496
 Del (5) 0 1 1.000
 −7/del (7) 2 5 0.278
 11q23 2 1 1.000
 Others 3 11 0.028
 Complex 5 20 0.001
 No data 2 1 1.000
Gene mutation
 FLT3 (±) 33/54 16/70 0.007
 NPM1 (±) 34/53 14/72 0.001
 DNMT3A (±) 27/60 15/71 0.051
 IDH2 (±) 9/78 8/78 1.000
 IDH1 (±) 8/79 8/78 1.000
 TET2 (±) 4/83 11/75 0.063
 RUNX1 (±) 10/77 14/72 0.388
 TP53 (±) 2/85 12/74 0.005
 NRAS (±) 5/82 7/79 0.566
 CEBPA (±) 7/80 6/80 1.000
 WT1 (±) 7/80 3/83 0.329
 PTPN11 (±) 4/83 4/82 1.000
 KIT (±) 3/84 4/82 0.720
 U2AF1 (±) 1/86 6/80 0.064
 KRAS (±) 4/83 3/83 1.000
  1. AML acute myeloid leukemia, WBC white blood cells, PB peripheral blood, BM bone marrow, FAB French-American-British