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Fig. 3 | Cancer Cell International

Fig. 3

From: Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL

Fig. 3

Synergistic effects of DMAMCL with etoposide or cisplatin in NB cells. NGP and BE2 cells were treated with different concentrations of DMAMCL with etoposide or cisplatin alone or in combination for 72 h. The combination index (CI) was analyzed using CompuSyn. CI < 1 indicates synergism, CI = 1 reflects an additive effect, and CI > 1 indicates antagonism. Cell confluence and survival were detected using Incucyte ZOOM and CCK-8 assays, respectively. A CI values of NGP and BE2 cells treated with the combination of DMAMCL and etoposide. B CI values of NGP and BE2 cells treated with the combination of DMAMCL and cisplatin. C Confluence of NGP and BE2 cells treated with the indicated concentration of DMAMCL and etoposide alone or in combination, *p < 0.05; **p < 0.01; ***p < 0.001. D Confluence of NGP and BE2 cells treated with the indicated concentration of DMAMCL and cisplatin alone or in combination. E Survival of NGP and BE2 cells treated with the indicated concentration of DMAMCL and etoposide alone or in combination. F Survival of NGP and BE2 cells treated with the indicated concentration of DMAMCL and cisplatin alone or in combination

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