Fig. 4

The combination of DMAMCL and etoposide increased antitumor effects and prolonged the survival of mice compared to either agent alone. Xenograft mouse models were established as described in Fig. 2. NGP tumor-bearing mice were treated with DMAMCL (75 mg/kg) or etoposide (15 mg/kg) alone or in combination for 21 days. BE2 tumor-bearing mice were treated with DMAMCL (75 or 100 mg/kg) or etoposide (15 mg/kg) alone or in combination for 21 days. A Tumor volume and survival curves of NGP tumor-bearing mice. Error bar: SE, ns (not significant): DMAMCL/Etoposide vs DMAMCL + Etoposide, *p < 0.05; **p < 0.01; ***p < 0.001, NGP (n = 10). B Tumor volume and survival curves of BE2 tumor-bearing mice. Error bar: SE, ns (not significant): DMAMCL/Etoposide vs DMAMCL + Etoposide, *p < 0.05; **p < 0.01; ***p < 0.001, BE2 (n = 10)