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Fig. 6 | Cancer Cell International

Fig. 6

From: Antitumor effects of the small molecule DMAMCL in neuroblastoma via suppressing aerobic glycolysis and targeting PFKL

Fig. 6

PFKL overexpression partially blocked DMAMCL-induced NB cell death. NGP and BE2 cells were transfected with PFKL overexpression or control plasmids for 16 h before being treated with DMAMCL for 72 h. Cell confluence, survival, and apoptosis were detected as described in Fig. 1. A PFKL expression in NGP and BE2 cells transfected with PFKL overexpression or control plasmids detected using western blotting. B PFKL expression in NGP and BE2 cells treated with DMAMCL + PFKL overexpression or control plasmids. C Confluence and survival of NGP cells treated with DMAMCL + PFKL overexpression or control plasmids, ns (not significant): NC vs OE-PFKL, *p < 0.05; **p < 0.01; ***p < 0.001. D Confluence and survival of BE2 cells treated with DMAMCL + PFKL overexpression or control plasmids. E Proportion of apoptotic NGP and BE2 cells treated with DMAMCL + PFKL overexpression or control plasmids. Data represent the mean ± SD of three independent experiments, *p < 0.05; **p < 0.01; ***p < 0.001

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