Table 2 The prognostic IRGPs and their risk coefficients involved in PRSM
From: Comprehensive analysis of prognostic immune-related genes and drug sensitivity in cervical cancer
IRG 1 | Immune-related function | IRG 2 | Immune-related function | Coef. |
|---|---|---|---|---|
BTLA | Negatively regulating antigen receptor signaling | GPR174 | Putative receptor for purines coupled to G-proteins | 0.068936 |
CD244 | Regulating innate and adaptive immune response | GPR174 | Putative receptor for purines coupled to G-proteins | 0.311926 |
CD28 | T cell activation | FASLG | Termination of immune responses | 0.279403 |
CD80 | T-lymphocyte activation | RGS18 | Inhibiting signal transduction | − 0.32299 |
CERKL | Regulate autophagy | RHOH | Negative regulator of hematopoietic progenitor cell | − 0.14509 |
CLEC4A | Regulating immune reactivity | LILRB4 | Down-regulation of the immune response and the development of tolerance | 0.065819 |
CYTH4 | Activation of ARF factors | STAC3 | – | − 0.33071 |
EVI2B | Hematopoietic progenitor cells differentiation | SLAMF7 | Regulating innate and adaptive immune response | − 0.41131 |
FCRL3 | B-cell proliferation | LY9 | Negative regulator of the immune response | − 0.13661 |
FGR | Regulation of immune responses (including neutrophil, monocyte, macrophage and mast cell functions) | IL10RA | Participating in IL10-mediated anti-inflammatory functions | 0.386338 |
FOXP3 | The development and inhibitory function of regulatory T-cells (Treg) | RASAL3 | Playing an important role in the expansion and functions of natural killer T (NKT) cells | − 0.42278 |
FUT7 | Involved in cell and matrix adhesion during leukocyte trafficking and fertilization | TFEC | Transcriptional regulator | 0.190542 |
GPR34 | Orphan receptor | STAC3 | – | 0.345396 |
GYPC | Regulating the stability of red cells | LST1 | Involved in dendritic cell maturation | 0.097751 |
IGSF6 | Regulating the function of CD8 + T effector cells | TNFSF13B | Involved in the stimulation of B- and T-cell function | 0.058717 |
LCP2 | Involved in T-cell antigen receptor mediated signaling | SLAMF8 | B-lineage commitment and/or modulation of signaling | 0.241523 |
LY9 | Negative regulator of the immune response | ZC3H12D | Degradation of interleukin IL-6 mRNA level in activated macrophages | 0.250874 |
NLRC3 | Negative regulator of the innate immune response | SIGLEC1 | Macrophage-restricted adhesion molecule | 0.005176 |
SAMD9L | Involved in endosome fusion | TMEM140 | Inhibition of viral proliferation | − 0.18399 |