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Fig. 5 | Cancer Cell International

Fig. 5

From: Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway

Fig. 5

MNTX and PP1 inhibit the morphine-induced activation of the Src/PI3K/AKT/mTOR signaling pathway. a Levels of total and phosphorylated Src, PI3K, AKT, and mTOR proteins in H460 non-small cell lung cancer cells treated with drugs. b Quantitative analysis of phospho-Src levels normalized to Src levels. c Quantitative analysis of phospho-PI3K levels normalized to PI3K levels. d Quantitative analysis of phospho-AKT levels normalized to AKT levels. e Quantitative analysis of phospho-mTOR levels normalized to mTOR levels, as shown in (a). In all experiments, cells were treated with the drugs for 48 h. The concentrations of morphine and MNTX were 0.1 μg/μL, the concentration of PP1 was 5 μM, and the control groups were treated with NS and DMSO at the same volumes. All data are presented as the means ± SD, *p < 0.05, **p < 0.01

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