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Fig. 7 | Cancer Cell International

Fig. 7

From: Morphine promotes the malignant biological behavior of non-small cell lung cancer cells through the MOR/Src/mTOR pathway

Fig. 7

Morphine promotes tumor growth by activating the Src/PI3K/AKT/mTOR pathway in nude mice. a The effect of morphine (1.5 mg/kg) on tumorigenesis in nude mice was measured in a xenograft trial. b Tumor growth curve in vivo: the horizontal axis represents the growth time and the vertical axis represents tumor size (n = 3; ***p < 0.001). c Comparison of tumor tissue weights between the morphine group and the control group (n = 3; **p < 0.01), d Levels of total and phosphorylated Src, PI3K, AKT, and mTOR proteins in tumors. e Quantitative analysis of Src and phospho-Src levels. f Quantitative analysis of PI3K and phospho-PI3K levels. g. Quantitative analysis of AKT and phospho-AKT levels. h Quantitative analysis of mTOR and phospho-mTOR levels. The control group was treated NS according to body weight. The data are presented as the means ± SD, *p < 0.05

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Cancer Cell International

ISSN: 1475-2867

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